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Friday, Sep 9th, 2016
Coarse-graining discrete cell cycle models: Introduction One observation that often goes underappreciated in computational biology discussions is that a computational model is often a model of a model of a model ... [read more]

Tuesday, Aug 30th, 2016
Some quick math to calculate numerical convergence rates: I find myself needing to re-derive this often enough that it’s worth jotting down for current and future students. Introduction A very common task in our ... [read more]

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PhysiCell: an open source physics-based cell simulator

Download the latest version (1.0.0)


Project goals

PhysiCell aims to provide a robust, scalable code for simulating large systems of cells in 3-D tissues on standard desktop computers. Among our design goals:

What's New Back to top

Coming soon -- method paper in the works!

Method, accuracy, and performance Back to top

Coming soon -- method paper in the works!

Screenshots and examples Back to top

Coming soon ...

Licensing and disclaimers Back to top

PhysiCell is licensed under the (3-Clause) BSD License. It is GPL v2 and v3 compatible, and suitable for commercial use in many circumstances.

PhysiCell is an academic/scientific code, and it should not be used as the basis for individual medical decisions. (That's what peer review, clinical trials, and FDA oversight are for!) Always consult your physician when making medical decisions.

Downloads Back to top

BioFVM is available for download at SourceForge. Each download includes a tutorial and code examples.

Most recent versions

Version Release Date Download link
1.0.0 12 September 2016 []
Notes: First public release

Support Back to top

For support, please contact Paul Macklin.

If you plan to use PhysiCell in a grant proposal, please consider including Paul Macklin as a Co-I or consultant for more dedicated support.

Development Roadmap Back to top

More soon.

How to Cite PhysiCell Back to top

For now, please reference PhysiCell by the project website at We will update this citation information once PhysiCell has been submitted for publication.

You can also cite an earlier (2-D) version of the model by our 2012 paper in the Journal of Theoretical Biology:

P. Macklin, M.E. Edgerton, A.M. Thompson, and V. Cristini. Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): From microscopic measurements to macroscopic predictions of clinical progression. J. Theor. Biol. 301:122-40, 2012. DOI: 10.1016/j.jtbi.2012.02.002.

Some Publications and Projects that cite PhysiCell

Nothing just yet. :-)

Additional topics Back to top

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